二甲双胍用于辅助生殖前对多囊卵巢综合征女性妊娠结局的影响
Metformin Use Before Assisted Reproductive Technology and Pregnancy Outcomes in Women With Polycystic Ovary Syndrome: A Nationwide Cohort Study
作者：Yongtai Cho、Yeon Soo Park、Yubin Lee、HyunJoo Lim、Ju‐Young Shin、Soo‐Heon Kwak
单位：Department of Pharmacy, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.；Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.；Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.；Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, South Korea.；College of Pharmacy, Seoul National University, Seoul, South Korea.
摘要
发表在《Clinical Pharmacology & Therapeutics》的全国性队列研究，探讨多囊卵巢综合征（PCOS）女性在接受辅助生殖技术（ART）前使用二甲双胍与妊娠结局的关联。研究结果为临床用药决策提供循证依据。
AI 主编 · 推荐理由推荐理由
二甲双胍在PCOS助孕中的应用长期存在争议。该全国队列研究提供了较高级别临床证据，直接影响生殖内分泌领域的用药规范和注册申报中的说明书适应症拓展策略。